Pokhara University (PU) | Syllabus
Pharmaceutical Chemistry I (General Chemistry)
B.Pharm (Bachelor of Pharmaceutical Sciences)
For: First Year | First Semester
PHC 171 | Credit Hours: 3

Course Objectives:
This course is designed to understand general principles of chemistry with principles of qualitative and quantitative analysis. This course will enable the students to understand the general nature of pharmaceutical constituents.

Course Contents:

1. Atomic Structure : 8 hours
   Bohr’s theory and refinements, Wave mechanical model of the atom, Matter wave, de Broglie’s equation, Heisenberg’s uncertainty principle, Shapes of s, p, d orbitals, Quantum numbers and their significance, Energy level diagram
2. Chemical Bonding : 10 hours
   General characteristics of covalent bond, electrovalent bond, coordinate covalent bond, hydrogen bond, and Van der Waals force and their biological significance, Hybridization, Inductive effective, Electrometric effect, Mesomerism, Resonance, Hyperconjugation, Atomic Orbital, Molecular orbital, Hybrid Orbital, Molecular orbital, Structure of Water, Ammonia, Methane, Ethylene, Acetylene, Benzene
3. Periodic Table : 7 hours
   Periodicity of element, s, p, d, f blocks, Long form of periodic table, Discussion of properties (atomic, ionic and covalent radii, ionization potential, screening or shielding effect, electronegetivity, electron affinity)
4. Nuclear Chemistry : 6 hours
   Composition of nucleus (nuclear stability), Binding energy, Radioactivity, Half-life determination, Nuclear reaction
5. Coordination Chemistry : 5 hours
   Werner’s theory, Nomenclature, Isomerism, Valence bond theory, Crystal field theory
6. Principles of Qualitative and Quantitative Analysis : 9 hours
   Solubility product, Common ion effect, Their application in group separation, Principles of gravimetric and volumetric analysis

Reference Books:

1. Samuel H. Maron and Carl F. Prutton: Principles of Physical Chemistry (4th Ed.) 1972, Oxford and IBM Publishing Co. Pvt. Ltd., New Delhi.
2. B. S. Bahl, G. D. Tuli and Arun Bahl: Essentials of Physical Chemistry (24th Ed.) 2000, S. Chand and Company Ltd., New Delhi.
3. F. Albert Cotton, Geoffrey Wilkinson and Paul L. Gaus: Basic Inorganic Chemistry (3rd Ed.) 2001, John Wiley and Sons Inc., New York.
4. Satya Prakash, G. D. Tuli, S. K. Basu, and R. D. Madan: Advanced Inorganic Chemistry (18th Ed.) Vol I, 2000, S. Chand and Company Ltd., New Delhi.
5. G. Svehla: Vogel’s Qualitative Inorganic Analysis (7th Ed.) 1998, Longman Group Limited., New York.
6. G. H. Jeffery, J. Bassett, J. Mendham, R. C. Denney Vogel’s Quantitative Chemical Analysis (5th Ed.) 1999, Addison Wisley Longman Inc., New York.